The PA28 Complex: A Potential Drug Target and Biomarker (P16678)

Target Name: PA28 Complex

NCBI ID: P16678

PA28 Complex

Other Name(s): PA28 | REG | 11S regulatory particle | Proteasome activator complex

The PA28 Complex: A Potential Drug Target and Biomarker

The PA28 complex is a protein complex that is involved in the regulation of various cellular processes that are critical for cell survival and growth. The complex consists of three subunits: PA28, PA28/P161, and PA28/P162. Each subunit of the PA28 complex plays a distinct role in the regulation of different cellular processes, and the complex has been implicated in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The PA28 complex has been identified as a potential drug target due to its involvement in several cellular processes that are associated with the development of diseases. For example, the PA28 complex has been shown to be involved in the regulation of cell cycle progression, apoptosis, angiogenesis, and inflammation. Additionally, the complex has been implicated in the development of various cancers, including breast, ovarian, and colorectal cancers.

One of the key challenges in studying the PA28 complex is its complex structure and the interactions between its subunits. Despite the efforts of researchers, the precise mechanisms by which the PA28 complex functions are not well understood. However, several studies have identified key components of the complex and have provided new insights into its functions.

One of the most well-studied subunits of the PA28 complex is PA28 itself. PA28 is a 28-kDa protein that is involved in the regulation of the G1/S transition, which is a critical step in the cell cycle. PA28 has been shown to interact with several key transcription factors, including nuclear factor of activating T-cells (NFAT), transcription factor-promoter binding protein (PBP), and transcription factor-binding domain (TF-BDD). The interaction ability of PA28 and its function Closely related, as these interactions are key to PA28's role in cell cycle regulation.

PA28/P161 and PA28/P162 are the other two subunits. PA28/P161 is a protein composed of two subunits, and PA28/P162 is a single subunit. These three subunits are involved in cell cycle regulation and the regulation of apoptosis. For example, PA28/P161 plays an important role in the S phase and G2 phase of the cell cycle, while PA28/P162 is mainly involved in the regulation of apoptosis.

Some research results indicate that PA28 and its interacting small subunits can interact with drug molecules and cause cell cycle arrest and apoptosis. These drug molecules include chemicals, biologics, and drugs. These drug molecules can inhibit the function of PA28, leading to cell cycle arrest, apoptosis and tumor growth. Therefore, PA28 and its interacting small subunits are potential drug targets.

In addition, some studies have also shown that PA28 and its interacting small subunits can regulate the function of immune cells. For example, PA28 can affect the activation and memory of T cells, and can also affect the proliferation and differentiation of B cells. These findings provide new ideas for studying the role of PA28 in immune regulation.

The pharmacological and biological significance of PA28 and its interacting small subunits is unclear. Future research will focus on understanding the molecular mechanisms of PA28 and its interacting small subunits and determining their potential as drug targets and mechanisms of action. The role of PA28 and its interacting small subunits in diseases, including cancer, neurodegenerative diseases, and immune diseases, can also be studied. This will help develop new treatments that improve patients' quality of life and extend their lives.

Protein Name: PA28 Complex

The "PA28 Complex Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PA28 Complex comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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